Abdominal Aortic Aneurysms– Simple Treatment or Prevention

Study Overview


poster

Please review the AAA STOP research poster from the Cardiovascular Institute retreat poster session in February 2007. It provides a brief overview of each project. The specific aims for each project are listed below.


Project II: Signature Protein Profiles to Identify AAAs

Specific Aim 1:   
To develop an antibody-based planar array providing simultaneous abundance measurements for approximately 50 serum markers of inflammation and proteases activity

Specific Aim 2:   
To conduct a serum marker study comparing cases with AAA and matched controls to identify protein patterns that correlate with AAA formation

Specific Aim 3:   
To conduct a longitudinal prospective study in cases to identify predictors of aneurysm progression

Specific Aim 4:   
To determine protein profiles in patients undergoing active intervention for AAA and determine if beneficial response to therapy can be ascertained

Project III:  Rest and Exercise Hemodynamics in AAA Progression

Specific Aim 1:   
Quantify time-varying abdominal aortic anatomy in AAA patients

Specific Aim 2:   
Quantify abdominal aortic blood flow at rest and during dynamic exercise using a custom MR-compatible bike in a 0.5T open MRI

Specific Aim 3:   
Develop and validate computational methods to model blood flow, pressure, and wall motion in “patient-specific” computational models of the abdominal aorta of patients with small AAA randomized to chronic exercise therapy or standard therapy

Project IV:  Evaluation of Exercise Therapy for Small AAA

Specific Aim 1A: 
Validate lifetime physical activity as an independent AAA disease risk factor
                       
Specific Aim 1B: 
Correlate exercise capacity with aortic diameter

Specific Aim 2:   
Prospectively evaluate the ability of exercise training to reduce AAA progression

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